{"id":1190651,"date":"2021-05-06T14:28:28","date_gmt":"2021-05-06T18:28:28","guid":{"rendered":"https:\/\/patientworthy.wpengine.com\/?p=1190651"},"modified":"2021-05-06T14:28:28","modified_gmt":"2021-05-06T18:28:28","slug":"des-chercheurs-ont-peut-etre-trouve-un-traitement-plus-efficace-de-la-maladie-de-pompe","status":"publish","type":"post","link":"https:\/\/patientworthy.com\/fr\/2021\/05\/06\/des-chercheurs-ont-peut-etre-trouve-un-traitement-plus-efficace-de-la-maladie-de-pompe\/","title":{"rendered":"Des chercheurs ont peut-\u00eatre trouv\u00e9 un traitement plus efficace de la maladie de Pompe"},"content":{"rendered":"<p><em><span class=\"TextRun Highlight SCXW246017672 BCX0\" lang=\"FR-FR\" xml:lang=\"FR-FR\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW246017672 BCX0\">Tous les documents publi\u00e9s sur PatientWorthy.com sont r\u00e9dig\u00e9s en anglais. Pour la commodit\u00e9 de notre public non anglophone, les traductions de ces documents sont fournies par l\u2019interm\u00e9diaire d\u2019un logiciel de traduction automatique aliment\u00e9 par Google Translate. Toutes les traductions sont fournies en tant que telles, sans garantie d\u2019aucune sorte, explicite ou implicite, quant \u00e0 l\u2019exactitude, la fiabilit\u00e9 ou la justesse de la traduction. Certains contenus (tels que les images, les vid\u00e9os, le Flash, etc.) peuvent ne pas \u00eatre traduits avec pr\u00e9cision en raison des limitations du logiciel de traduction.\u202f<\/span><\/span><span class=\"TextRun Highlight SCXW246017672 BCX0\" lang=\"FR-FR\" xml:lang=\"FR-FR\" data-contrast=\"none\"><span class=\"ContextualSpellingAndGrammarError SCXW246017672 BCX0\">Veuillez vous<\/span><\/span><span class=\"TextRun Highlight SCXW246017672 BCX0\" lang=\"FR-FR\" xml:lang=\"FR-FR\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW246017672 BCX0\">\u202fr\u00e9f\u00e9rer \u00e0 la version anglaise de PatientWorthy.com pour le texte officiel.<\/span><\/span><\/em><span class=\"TextRun Highlight SCXW246017672 BCX0\" lang=\"FR-FR\" xml:lang=\"FR-FR\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW246017672 BCX0\">\u202f<\/span><\/span><\/p>\n<p><span data-contrast=\"none\">Selon\u00a0<\/span><a href=\"https:\/\/www.news-medical.net\/news\/20210416\/New-and-more-effective-treatment-for-Pompe-disease.aspx\"><span data-contrast=\"none\">News\u00a0<\/span><span data-contrast=\"none\">Medical<\/span><\/a><span data-contrast=\"none\">, des chercheurs de l&rsquo;Universit\u00e9 de Cincinnati ont pr\u00e9sent\u00e9 des r\u00e9sultats sur une option de traitement potentiellement nouvelle et efficace pour la maladie de Pompe lors de la r\u00e9union annuelle virtuelle de l&rsquo;American\u00a0<\/span><span data-contrast=\"none\">Academy<\/span><span data-contrast=\"none\">\u00a0of\u00a0<\/span><span data-contrast=\"none\">Neurology<\/span><span data-contrast=\"none\">. Actuellement, la maladie de Pompe est trait\u00e9e par des th\u00e9rapies enzymatiques substitutives. Plus pr\u00e9cis\u00e9ment, les patients re\u00e7oivent\u00a0<\/span><span data-contrast=\"none\">Myozyme<\/span><span data-contrast=\"none\">\u00a0(<\/span><span data-contrast=\"none\">alglucoside<\/span><span data-contrast=\"none\">\u00a0alfa). Cependant, les chercheurs pensent maintenant qu&rsquo;une autre th\u00e9rapie de remplacement enzymatique appel\u00e9e\u00a0<\/span><span data-contrast=\"none\">avalglucosidase<\/span><span data-contrast=\"none\">\u00a0alfa pourrait am\u00e9liorer les r\u00e9sultats des patients et offrir une meilleure qualit\u00e9 de soins.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Avalglucoside<\/span><\/b><b><span data-contrast=\"none\">\u00a0Alfa<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Chez les patients atteints de la maladie de Pompe, les mutations du g\u00e8ne GAA emp\u00eachent le corps de cr\u00e9er une prot\u00e9ine qui d\u00e9compose le glycog\u00e8ne. En cons\u00e9quence, le glycog\u00e8ne s&rsquo;accumule, causant des dommages aux muscles et\u00a0<\/span><span data-contrast=\"none\">aux organes. La th\u00e9rapie de remplacement enzymatique permet aux patients de recevoir les enzymes et les prot\u00e9ines n\u00e9cessaires pour aider \u00e0 d\u00e9composer ce glycog\u00e8ne, soulager les sympt\u00f4mes et am\u00e9liorer les taux de survie des patients.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Aujourd&rsquo;hui, les chercheurs pensent avoir d\u00e9couvert une th\u00e9rapie enzymatique plus s\u00fbre, efficace et bien tol\u00e9r\u00e9e que la norme de soins actuelle. Selon le Dr Hani\u00a0<\/span><span data-contrast=\"none\">Kushlaf<\/span><span data-contrast=\"none\">, MD, les chercheurs ont men\u00e9 un essai clinique pour \u00e9valuer l&rsquo;<\/span><span data-contrast=\"none\">avalglucoside<\/span><span data-contrast=\"none\">\u00a0alfa par rapport \u00e0 l&rsquo;<\/span><span data-contrast=\"none\">alglucoside<\/span><span data-contrast=\"none\">\u00a0alfa. \u00c9tant donn\u00e9 que l&rsquo;essai \u00e9tait en double aveugle, ni les patients ni les chercheurs ne savaient qui recevait quel traitement.\u00a0<\/span><span data-contrast=\"none\">Au final<\/span><span data-contrast=\"none\">, 51 patients atteints de la maladie de Pompe ont re\u00e7u de l&rsquo;<\/span><span data-contrast=\"none\">avalglucoside<\/span><span data-contrast=\"none\">\u00a0alfa. Les chercheurs ont d\u00e9termin\u00e9 que cette th\u00e9rapie de remplacement\u00a0<\/span><span data-contrast=\"none\">enzymatique:<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Am\u00e9lioration de l&rsquo;endurance, de la force musculaire et de la fonction des muscles respiratoires<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Am\u00e9lioration de la qualit\u00e9 de vie (QOL)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><b><span data-contrast=\"none\">Maladie de Pompe<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">On estime qu&rsquo;un Am\u00e9ricain sur 40000 souffre de la maladie de Pompe, une maladie g\u00e9n\u00e9tique caus\u00e9e par des mutations g\u00e9n\u00e9tiques GAA. Lorsque le glycog\u00e8ne s\u2019accumule dans les cellules du corps, il provoque des probl\u00e8mes de fonctionnement des muscles, des organes et des tissus. Le plus souvent, cela affecte n\u00e9gativement le c\u0153ur et les muscles respiratoires, provoquant des r\u00e9actions secondaires potentiellement dangereuses ou mortelles.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Au total, il existe trois formes principales de la maladie de\u00a0<\/span><span data-contrast=\"none\">Pompe:<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"none\">D\u00e9but infantile.<\/span><\/b><span data-contrast=\"none\">\u00a0Dans la forme infantile, les sympt\u00f4mes apparaissent g\u00e9n\u00e9ralement dans les quelques mois (~ 3) suivant la naissance. Dans l&rsquo;ensemble, c&rsquo;est la forme la plus grave de cette condition. Sans traitement, la forme infantile pourrait \u00eatre mortelle dans les 2 ans. Les sympt\u00f4mes\u00a0<\/span><span data-contrast=\"none\">comprennent:<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"3\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Hypertrophie du foie<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"3\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Faible tonus musculaire<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"3\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Faiblesse musculaire<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"3\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Malformations cardiaques<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"3\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Retard de croissance<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"3\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Difficult\u00e9s d&rsquo;alimentation<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"3\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Perte auditive<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"3\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Une grande langue saillante<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><span data-contrast=\"none\">Difficult\u00e9 \u00e0 respirer<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"none\">D\u00e9but infantile non classique.<\/span><\/b><span data-contrast=\"none\">\u00a0Dans la forme infantile non classique, les sympt\u00f4mes deviennent g\u00e9n\u00e9ralement apparents vers l&rsquo;\u00e2ge d&rsquo;un an. Contrairement \u00e0 la forme infantile de la maladie de Pompe, les patients atteints de la substance non classique \u00e0 d\u00e9but infantile ne pr\u00e9sentent g\u00e9n\u00e9ralement pas autant d&rsquo;insuffisance cardiaque. Sans traitement, cette forme peut \u00eatre mortelle avant la petite enfance. Les sympt\u00f4mes\u00a0<\/span><span data-contrast=\"none\">comprennent:<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"4\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Faiblesse musculaire progressive<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"4\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Hypertrophie du\u00a0<\/span><span data-contrast=\"none\">coeur<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"4\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">D\u00e9tresse respiratoire<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"4\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"none\">D\u00e9veloppement moteur lent<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"none\">Apparition tardive.<\/span><\/b><span data-contrast=\"none\">\u00a0Dans cette forme finale, les sympt\u00f4mes n&rsquo;apparaissent souvent qu&rsquo;\u00e0 l&rsquo;\u00e2ge adulte. En g\u00e9n\u00e9ral, cette forme n&rsquo;implique pas le c\u0153ur, bien que les patients puissent souffrir d&rsquo;insuffisance respiratoire. D&rsquo;autres sympt\u00f4mes\u00a0<\/span><span data-contrast=\"none\">comprennent:<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"5\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Faiblesse musculaire progressive<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"5\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Difficult\u00e9 \u00e0 respirer, \u00e0 m\u00e2cher ou \u00e0 avaler<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"5\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">La scoliose<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"5\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">Paupi\u00e8res sup\u00e9rieures tombantes<\/span><\/li>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"5\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">Anomalies des vaisseaux sanguins<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><span data-contrast=\"none\">En savoir plus sur\u00a0<\/span><a href=\"https:\/\/patientworthy.com\/pompe-disease\/\"><span data-contrast=\"none\">la maladie de Pompe<\/span><\/a><span data-contrast=\"none\">.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:360,&quot;469777462&quot;:[916,1832,2748,3664,4580,5496,6412,7328,8244,9160,10076,10992,11908,12824,13740,14656],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tous les documents publi\u00e9s sur PatientWorthy.com sont r\u00e9dig\u00e9s en anglais. Pour la commodit\u00e9 de notre public non anglophone, les traductions de ces documents sont fournies par l\u2019interm\u00e9diaire d\u2019un logiciel de traduction automatique aliment\u00e9 par Google Translate. Toutes les traductions sont fournies en tant que telles, sans garantie d\u2019aucune sorte, explicite ou implicite, quant \u00e0 l\u2019exactitude, [&hellip;]<\/p>\n","protected":false},"author":1217,"featured_media":360130,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[13986],"tags":[],"_links":{"self":[{"href":"https:\/\/patientworthy.com\/fr\/wp-json\/wp\/v2\/posts\/1190651"}],"collection":[{"href":"https:\/\/patientworthy.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/patientworthy.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/patientworthy.com\/fr\/wp-json\/wp\/v2\/users\/1217"}],"replies":[{"embeddable":true,"href":"https:\/\/patientworthy.com\/fr\/wp-json\/wp\/v2\/comments?post=1190651"}],"version-history":[{"count":0,"href":"https:\/\/patientworthy.com\/fr\/wp-json\/wp\/v2\/posts\/1190651\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/patientworthy.com\/fr\/wp-json\/wp\/v2\/media\/360130"}],"wp:attachment":[{"href":"https:\/\/patientworthy.com\/fr\/wp-json\/wp\/v2\/media?parent=1190651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/patientworthy.com\/fr\/wp-json\/wp\/v2\/categories?post=1190651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/patientworthy.com\/fr\/wp-json\/wp\/v2\/tags?post=1190651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}