Gorham-Stout Disease (GSD)
What is Gorham-Stout disease?
Gorham-Stout disease (GSD) can be referred to by multiple names, including disappearing bone disease and massive osteolysis. Progressive bone loss and proliferation of the lymphatic vessels are key characteristics, with the spine, pelvis, ribs, skull, jaw, and clavicle most commonly affected.
What are the symptoms of Gorham-Stout disease?
Symptoms can vary depending on which bone is affected. Pain and swelling are two of the main symptoms, and affected bones may fracture easily as well.
If the jaw is affected, loose teeth, facial deformity, fractures, and pain are the symptoms. Issues with the thoracic cage lead to chylothorax. This brings symptoms like chest pain, difficulty breathing, rapid breathing, and respiratory complications. At times, fluid can accumulate in the abdominal cavity or around the heart.
What causes Gorham-Stout disease?
There is no known cause for GSD. Medical professionals have been unable to identify any cause, whether that is environmental, genetic, or immunological.
How is Gorham-Stout disease diagnosed?
Doctors will diagnose this condition by ruling out others, such as Paget’s disease or rheumatoid arthritis. A clinical evaluation and various tests will be performed, including biopsies and imaging tests.
What are the treatments for Gorham-Stout disease?
Treatment is symptomatic. Surgery and bone grafts have been used, as has radiation therapy.
Where can I find out more about Gorham-Stout disease?