{"id":1377492,"date":"2021-07-08T10:40:38","date_gmt":"2021-07-08T14:40:38","guid":{"rendered":"https:\/\/patientworthy.wpengine.com\/?p=1377492&#038;preview=true&#038;preview_id=1377492"},"modified":"2021-07-08T10:40:38","modified_gmt":"2021-07-08T14:40:38","slug":"%d0%ba%d0%be%d1%81%d0%b5%d0%bb%d1%83%d0%b3%d0%be-%d0%be%d0%b4%d0%be%d0%b1%d1%80%d0%b5%d0%bd-%d0%b5%d1%81-nf1-pn","status":"publish","type":"post","link":"https:\/\/patientworthy.com\/ru\/2021\/07\/08\/%d0%ba%d0%be%d1%81%d0%b5%d0%bb%d1%83%d0%b3%d0%be-%d0%be%d0%b4%d0%be%d0%b1%d1%80%d0%b5%d0%bd-%d0%b5%d1%81-nf1-pn\/","title":{"rendered":"Koselugo \u0422\u0435\u043f\u0435\u0440\u044c \u041e\u0434\u043e\u0431\u0440\u0435\u043d \u0415\u0421 \u0434\u043b\u044f NF1 \u0438 PN"},"content":{"rendered":"<p>22 \u0438\u044e\u043d\u044f 2021 \u0433\u043e\u0434\u0430 <a href=\"https:\/\/www.pharmatimes.com\/news\/eu_green_lights_az,_msds_rare_disease_therapy_koselugo_1371957\">PharmaTimes Online<\/a> \u0441\u043e\u043e\u0431\u0449\u0438\u043b\u0430, \u0447\u0442\u043e \u0415\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u043a\u0430\u044f \u041a\u043e\u043c\u0438\u0441\u0441\u0438\u044f (\u0415\u041a) \u043f\u0440\u0435\u0434\u043e\u0441\u0442\u0430\u0432\u0438\u043b\u0430 \u0443\u0441\u043b\u043e\u0432\u043d\u043e\u0435 \u0440\u0430\u0437\u0440\u0435\u0448\u0435\u043d\u0438\u0435 \u043d\u0430 \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u041a\u043e\u0441\u0435\u043b\u0443\u0433\u043e (Koselugo) (\u0441\u0435\u043b\u0443\u043c\u0435\u0442\u0438\u043d\u0438\u0431) \u0434\u043b\u044f \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0443 \u0434\u0435\u0442\u0441\u043a\u0438\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u0442\u043e\u0437\u043e\u043c 1 \u0442\u0438\u043f\u0430 (NF1) \u0438 \u043f\u043b\u0435\u043a\u0441\u0438\u0444\u043e\u0440\u043c\u043d\u044b\u043c\u0438 \u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u043c\u0438 (<a href=\"https:\/\/radiopaedia.org\/articles\/plexiform-neurofibroma?lang=us\">PN<\/a>). \u0412 \u0446\u0435\u043b\u043e\u043c \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438\u0435 \u0437\u0430\u0432\u0438\u0441\u0435\u043b\u043e \u043e\u0442 \u0434\u0430\u043d\u043d\u044b\u0445 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f Phase 2 SPRINT Stratum 1. \u041f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u0430\u043d \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u044f\u043c\u0438 AstraZeneca \u0438 MSD.<\/p>\n<h2>Koselugo<\/h2>\n<p>\u0421\u043e\u0433\u043b\u0430\u0441\u043d\u043e <a href=\"https:\/\/www.astrazeneca.com\/media-centre\/press-releases\/2021\/koselugo-approved-in-the-eu-for-children-with-neurofibromatosis-type-1-and-plexiform-neurofibromas.html\">AstraZeneca<\/a>, \u041a\u043e\u0441\u0435\u043b\u0443\u0433\u043e &#8212; \u044d\u0442\u043e:<\/p>\n<blockquote><p>\u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440 \u043c\u0438\u0442\u043e\u0433\u0435\u043d-\u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0443\u0435\u043c\u044b\u0445 \u043a\u0438\u043d\u0430\u0437 \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043a\u0438\u043d\u0430\u0437 1 \u0438 2 (MEK1 \/ 2) [\u043a\u043e\u0442\u043e\u0440\u044b\u0435] \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0432\u044b\u0448\u0435\u0441\u0442\u043e\u044f\u0449\u0438\u043c\u0438 \u0440\u0435\u0433\u0443\u043b\u044f\u0442\u043e\u0440\u0430\u043c\u0438 \u043f\u0443\u0442\u0438 \u0432\u043d\u0435\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0439 \u0441\u0438\u0433\u043d\u0430\u043b\u044c\u043d\u043e\u0439 \u043a\u0438\u043d\u0430\u0437\u044b (ERK). \u0418 MEK, \u0438 ERK \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u043a\u0440\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u043a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442\u0430\u043c\u0438 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u0435\u043c\u043e\u0433\u043e RAS \u043f\u0443\u0442\u0438 RAF-MEK-ERK, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0447\u0430\u0441\u0442\u043e \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u043f\u0440\u0438 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u0442\u0438\u043f\u0430\u0445 \u0440\u0430\u043a\u0430.<\/p><\/blockquote>\n<p>\u0412 \u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u0435 \u0432\u0440\u0435\u043c\u044f \u041a\u043e\u0441\u0435\u043b\u0443\u0433\u043e \u043f\u043e\u043b\u0443\u0447\u0438\u043b \u043e\u0431\u043e\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u00ab\u041f\u0440\u043e\u0440\u044b\u0432 \u0432 \u0422\u0435\u0440\u0430\u043f\u0438\u0438\u00bb, \u00ab\u0420\u0435\u0434\u043a\u0438\u0435 \u0414\u0435\u0442\u0441\u043a\u0438\u0435 \u0417\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u00bb \u0438 \u00ab\u041e\u0440\u0444\u0430\u043d\u043d\u044b\u0435 \u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430\u00bb \u0432 \u0421\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u043d\u044b\u0445 \u0428\u0442\u0430\u0442\u0430\u0445. \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u043e\u043d \u043f\u043e\u043b\u0443\u0447\u0438\u043b \u0441\u0442\u0430\u0442\u0443\u0441 \u041e\u0440\u0444\u0430\u043d\u043d\u043e\u0433\u043e \u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0432 \u0415\u0421. \u042d\u0442\u043e \u0442\u0430\u043a\u0436\u0435 \u043f\u0435\u0440\u0432\u043e\u0435 \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u043d\u043e\u0435 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e \u0432 \u0415\u0421 \u0434\u043b\u044f \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 NF1.<\/p>\n<p>\u041d\u0435\u0434\u0430\u0432\u043d\u0435\u0435<a href=\"https:\/\/www.ema.europa.eu\/en\/human-regulatory\/marketing-authorisation\/conditional-marketing-authorisation\"> \u0443\u0441\u043b\u043e\u0432\u043d\u043e\u0435 \u0440\u0430\u0437\u0440\u0435\u0448\u0435\u043d\u0438\u0435 \u043d\u0430 \u043f\u0440\u043e\u0434\u0430\u0436\u0443<\/a> \u0431\u044b\u043b\u043e \u043f\u0440\u0435\u0434\u043e\u0441\u0442\u0430\u0432\u043b\u0435\u043d\u043e \u043a\u0430\u043a:<\/p>\n<blockquote><p>\u041f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u043e \u043d\u0435\u043c\u0435\u0434\u043b\u0435\u043d\u043d\u043e\u0439 \u0434\u043e\u0441\u0442\u0443\u043f\u043d\u043e\u0441\u0442\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u043f\u0435\u0440\u0435\u0432\u0435\u0448\u0438\u0432\u0430\u0435\u0442 \u0440\u0438\u0441\u043a, \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u0439 \u0441 \u0442\u0435\u043c, \u0447\u0442\u043e \u0432\u0441\u0435 \u0435\u0449\u0435 \u0442\u0440\u0435\u0431\u0443\u044e\u0442\u0441\u044f \u0434\u043e\u043f\u043e\u043b\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u0434\u0430\u043d\u043d\u044b\u0435.<\/p><\/blockquote>\n<p>\u041e\u0434\u043d\u0430\u043a\u043e \u0434\u0430\u043d\u043d\u044b\u0435 \u0444\u0430\u0437\u044b 2 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u0439 <em>\u0431\u044b\u043b\u0438<\/em> \u043c\u043d\u043e\u0433\u043e\u043e\u0431\u0435\u0449\u0430\u044e\u0449\u0438\u043c\u0438. \u0412\u043e \u0432\u0440\u0435\u043c\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0434\u0435\u0442\u0441\u043a\u0438\u0435 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u044b \u0441 \u043f\u043b\u0435\u043a\u0441\u0438\u0444\u043e\u0440\u043c\u043d\u044b\u043c\u0438 \u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u043c\u0438, \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u043c\u0438 \u0441 NF1, \u043b\u0435\u0447\u0438\u043b\u0438\u0441\u044c \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u043c \u041a\u043e\u0441\u0435\u043b\u0443\u0433\u043e. \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u0438 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0438\u043b\u0438, \u0447\u0442\u043e:<\/p>\n<ul>\n<li>\u0412 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 \u0431\u044b\u043b\u0430 \u0434\u043e\u0441\u0442\u0438\u0433\u043d\u0443\u0442\u0430 \u043e\u0431\u0449\u0430\u044f \u0447\u0430\u0441\u0442\u043e\u0442\u0430 \u043e\u0442\u0432\u0435\u0442\u0430 66%, \u043a\u043e\u0433\u0434\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043b\u0435\u0447\u0438\u043b\u0438 2 \u0440\u0430\u0437\u0430 \u0432 \u0434\u0435\u043d\u044c.<\/li>\n<li>\u041f\u043e\u043c\u0438\u043c\u043e \u0443\u043c\u0435\u043d\u044c\u0448\u0435\u043d\u0438\u044f \u0440\u0430\u0437\u043c\u0435\u0440\u0430 \u043d\u0435\u043e\u043f\u0435\u0440\u0430\u0431\u0435\u043b\u044c\u043d\u043e\u0439 \u043e\u043f\u0443\u0445\u043e\u043b\u0438, \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u041a\u043e\u0441\u0435\u043b\u0443\u0433\u043e \u0442\u0430\u043a\u0436\u0435 \u0443\u043b\u0443\u0447\u0448\u0438\u043b\u0430 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u043e \u0436\u0438\u0437\u043d\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 (QOL).<\/li>\n<li>\u041d\u0430\u043a\u043e\u043d\u0435\u0446, \u041a\u043e\u0441\u0435\u043b\u0443\u0433\u043e \u0441\u043d\u0438\u0437\u0438\u043b \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0431\u043e\u043b\u0438 \u0443 \u0434\u0435\u0442\u0441\u043a\u0438\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432.<\/li>\n<\/ul>\n<h2>\u041d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u0442\u043e\u0437<\/h2>\n<p>\u0412\u0441\u0435\u0433\u043e \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0443\u0435\u0442 \u0442\u0440\u0438 \u0444\u043e\u0440\u043c\u044b \u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u0442\u043e\u0437\u0430 &#8212; \u0440\u0435\u0434\u043a\u043e\u0433\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u043f\u043e\u0440\u0430\u0436\u0430\u044e\u0449\u0435\u0433\u043e \u043d\u0435\u0440\u0432\u043d\u0443\u044e \u0441\u0438\u0441\u0442\u0435\u043c\u0443. \u041f\u0440\u0438 \u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u0442\u043e\u0437\u0435 1 \u0442\u0438\u043f\u0430 (NF1) \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u043e\u0431\u044b\u0447\u043d\u043e \u043f\u043e\u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0432 \u043f\u0435\u0440\u0438\u043e\u0434 \u043c\u0435\u0436\u0434\u0443 \u0440\u043e\u0436\u0434\u0435\u043d\u0438\u0435\u043c \u0438 \u0440\u0430\u043d\u043d\u0438\u043c \u0434\u0435\u0442\u0441\u0442\u0432\u043e\u043c. \u041d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u0442\u043e\u0437 \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044e \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439 \u043d\u0430 \u0437\u0434\u043e\u0440\u043e\u0432\u043e\u0439 \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438. \u0425\u043e\u0442\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0438 \u0447\u0430\u0441\u0442\u043e \u0431\u044b\u0432\u0430\u044e\u0442 \u0434\u043e\u0431\u0440\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c\u0438, \u043e\u043d\u0438 \u043c\u043e\u0433\u0443\u0442 \u0441\u0442\u0430\u0442\u044c \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c\u0438.<\/p>\n<p>\u041f\u0430\u0446\u0438\u0435\u043d\u0442\u044b \u0441 NF1, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u044b\u043c \u043c\u0443\u0442\u0430\u0446\u0438\u044f\u043c\u0438 \u0433\u0435\u043d\u0430 <em>NF1<\/em>, \u0442\u0430\u043a\u0436\u0435 \u0438\u0441\u043f\u044b\u0442\u044b\u0432\u0430\u044e\u0442:<\/p>\n<ul>\n<li>\u041d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u043e\u0431\u0443\u0447\u0430\u0435\u043c\u043e\u0441\u0442\u0438<\/li>\n<li>\u0414\u0435\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u0438 \u043a\u043e\u0441\u0442\u0435\u0439<\/li>\n<li>\u041c\u044f\u0433\u043a\u0438\u0435 \u043d\u0435\u0440\u043e\u0432\u043d\u043e\u0441\u0442\u0438 \u043d\u0430 \/ \u043f\u043e\u0434 \u043a\u043e\u0436\u0435\u0439 (\u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u044b)<\/li>\n<li>\u041d\u0435\u0432\u044b\u0441\u043e\u043a\u0438\u0439 \u0440\u043e\u0441\u0442<\/li>\n<li>\u0413\u043e\u043b\u043e\u0432\u0430 \u0431\u043e\u043b\u044c\u0448\u0435\u0433\u043e \u0440\u0430\u0437\u043c\u0435\u0440\u0430<\/li>\n<li>\u041a\u0440\u043e\u0448\u0435\u0447\u043d\u044b\u0435 \u0448\u0438\u0448\u043a\u0438 \u043d\u0430 \u0440\u0430\u0434\u0443\u0436\u043a\u0430\u0445<\/li>\n<li>\u041f\u043b\u043e\u0441\u043a\u0438\u0435 \u0441\u0432\u0435\u0442\u043b\u043e-\u043a\u043e\u0440\u0438\u0447\u043d\u0435\u0432\u044b\u0435 \u043f\u044f\u0442\u043d\u0430 \u043d\u0430 \u043a\u043e\u0436\u0435 \u0438 \u0432\u0435\u0441\u043d\u0443\u0448\u043a\u0438 \u0432 \u043f\u043e\u0434\u043c\u044b\u0448\u043a\u0430\u0445 \/ \u043f\u0430\u0445\u0443<\/li>\n<\/ul>\n<p>\u0414\u0430\u043b\u0435\u0435, \u043f\u0440\u0438 NF2, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u043e\u043c \u043c\u0443\u0442\u0430\u0446\u0438\u044f\u043c\u0438 <em>NF2<\/em>, \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u044b \u0438\u0441\u043f\u044b\u0442\u044b\u0432\u0430\u044e\u0442:<\/p>\n<ul>\n<li>\u041f\u043e\u0442\u0435\u0440\u044f \u0441\u043b\u0443\u0445\u0430<\/li>\n<li>\u0422\u0438\u043d\u043d\u0438\u0442\u0443\u0441 (\u0437\u0432\u043e\u043d \u0432 \u0443\u0448\u0430\u0445)<\/li>\n<li>\u041f\u0440\u043e\u0431\u043b\u0435\u043c\u044b \u0441 \u0431\u0430\u043b\u0430\u043d\u0441\u043e\u043c \u0438 \u043a\u043e\u043e\u0440\u0434\u0438\u043d\u0430\u0446\u0438\u0435\u0439<\/li>\n<li>\u0413\u043e\u043b\u043e\u0432\u043d\u044b\u0435 \u0431\u043e\u043b\u0438<\/li>\n<\/ul>\n<p>\u0412\u043e \u043c\u043d\u043e\u0433\u0438\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043f\u043e\u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u0432 \u043f\u043e\u0434\u0440\u043e\u0441\u0442\u043a\u043e\u0432\u043e\u043c \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435. \u041d\u0430\u043a\u043e\u043d\u0435\u0446, \u043c\u0443\u0442\u0430\u0446\u0438\u0438 \u0433\u0435\u043d\u0430 <em>SMARCB1<\/em> \u0438\u043b\u0438 <em>NF2<\/em> \u0432\u044b\u0437\u044b\u0432\u0430\u044e\u0442 \u0448\u0432\u0430\u043d\u043d\u043e\u043c\u0430\u0442\u043e\u0437, \u043d\u0430\u0438\u0431\u043e\u043b\u0435\u0435 \u0442\u044f\u0436\u0435\u043b\u0443\u044e \u0438 \u0440\u0435\u0434\u043a\u0443\u044e \u0444\u043e\u0440\u043c\u0443, \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0443\u044e\u0449\u0443\u044e\u0441\u044f:<\/p>\n<ul>\n<li>\u0421\u0438\u043b\u044c\u043d\u0430\u044f \u0431\u043e\u043b\u044c<\/li>\n<li>\u041f\u043e\u0442\u0435\u0440\u044f \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u043c\u0430\u0441\u0441\u044b<\/li>\n<li>\u0422\u0435\u043b\u0435\u0441\u043d\u043e\u0435 \u043e\u043d\u0435\u043c\u0435\u043d\u0438\u0435 \/ \u0441\u043b\u0430\u0431\u043e\u0441\u0442\u044c<\/li>\n<li>\u041e\u043f\u0443\u0445\u043e\u043b\u0438 \u0447\u0435\u0440\u0435\u043f\u0430, \u0441\u043f\u0438\u043d\u043d\u043e\u043c\u043e\u0437\u0433\u043e\u0432\u044b\u0445 \u0438 \u043f\u0435\u0440\u0438\u0444\u0435\u0440\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043d\u0435\u0440\u0432\u043e\u0432.<\/li>\n<\/ul>\n<p>\u0423\u0437\u043d\u0430\u0439\u0442\u0435 \u0431\u043e\u043b\u044c\u0448\u0435 \u043e <a href=\"https:\/\/patientworthy.com\/neurofibromatosis\/\">\u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u0442\u043e\u0437\u0435 \u0437\u0434\u0435\u0441\u044c<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>22 \u0438\u044e\u043d\u044f 2021 \u0433\u043e\u0434\u0430 PharmaTimes Online \u0441\u043e\u043e\u0431\u0449\u0438\u043b\u0430, \u0447\u0442\u043e \u0415\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u043a\u0430\u044f \u041a\u043e\u043c\u0438\u0441\u0441\u0438\u044f (\u0415\u041a) \u043f\u0440\u0435\u0434\u043e\u0441\u0442\u0430\u0432\u0438\u043b\u0430 \u0443\u0441\u043b\u043e\u0432\u043d\u043e\u0435 \u0440\u0430\u0437\u0440\u0435\u0448\u0435\u043d\u0438\u0435 \u043d\u0430 \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u041a\u043e\u0441\u0435\u043b\u0443\u0433\u043e (Koselugo) (\u0441\u0435\u043b\u0443\u043c\u0435\u0442\u0438\u043d\u0438\u0431) \u0434\u043b\u044f \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0443 \u0434\u0435\u0442\u0441\u043a\u0438\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u0442\u043e\u0437\u043e\u043c 1 \u0442\u0438\u043f\u0430 (NF1) \u0438 \u043f\u043b\u0435\u043a\u0441\u0438\u0444\u043e\u0440\u043c\u043d\u044b\u043c\u0438 \u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u043c\u0438 (PN). \u0412 \u0446\u0435\u043b\u043e\u043c \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438\u0435 \u0437\u0430\u0432\u0438\u0441\u0435\u043b\u043e \u043e\u0442 \u0434\u0430\u043d\u043d\u044b\u0445 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f Phase 2 SPRINT Stratum 1. \u041f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u0430\u043d \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u044f\u043c\u0438 AstraZeneca \u0438 MSD. Koselugo \u0421\u043e\u0433\u043b\u0430\u0441\u043d\u043e [&hellip;]<\/p>\n","protected":false},"author":700,"featured_media":1194009,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ocean_front_end_style_editor":"no","ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","ocean_post_oembed":"","ocean_post_self_hosted_media":"","ocean_post_video_embed":"","ocean_link_format":"","ocean_link_format_target":"self","ocean_quote_format":"","ocean_quote_format_link":"post","ocean_gallery_link_images":"off","ocean_gallery_id":[]},"categories":[16308],"tags":[13179,16518,21651,13213,24358],"_links":{"self":[{"href":"https:\/\/patientworthy.com\/ru\/wp-json\/wp\/v2\/posts\/1377492"}],"collection":[{"href":"https:\/\/patientworthy.com\/ru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/patientworthy.com\/ru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/patientworthy.com\/ru\/wp-json\/wp\/v2\/users\/700"}],"replies":[{"embeddable":true,"href":"https:\/\/patientworthy.com\/ru\/wp-json\/wp\/v2\/comments?post=1377492"}],"version-history":[{"count":0,"href":"https:\/\/patientworthy.com\/ru\/wp-json\/wp\/v2\/posts\/1377492\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/patientworthy.com\/ru\/wp-json\/wp\/v2\/media\/1194009"}],"wp:attachment":[{"href":"https:\/\/patientworthy.com\/ru\/wp-json\/wp\/v2\/media?parent=1377492"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/patientworthy.com\/ru\/wp-json\/wp\/v2\/categories?post=1377492"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/patientworthy.com\/ru\/wp-json\/wp\/v2\/tags?post=1377492"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}