{"id":444052,"date":"2020-11-20T09:44:18","date_gmt":"2020-11-20T14:44:18","guid":{"rendered":"https:\/\/patientworthy.wpengine.com\/?p=444052&#038;preview=true&#038;preview_id=444052"},"modified":"2020-11-20T09:44:18","modified_gmt":"2020-11-20T14:44:18","slug":"%d0%b4%d0%be%d0%b7%d0%b8%d1%80%d0%be%d0%b2%d0%b0%d0%bd%d0%b8%d0%b5-garetosmab-%d0%bf%d1%80%d0%b8%d0%be%d1%81%d1%82%d0%b0%d0%bd%d0%be%d0%b2%d0%bb%d0%b5%d0%bd%d0%be-%d0%b2-%d0%b8%d1%81%d0%bf%d1%8b%d1%82","status":"publish","type":"post","link":"https:\/\/patientworthy.com\/ru\/2020\/11\/20\/%d0%b4%d0%be%d0%b7%d0%b8%d1%80%d0%be%d0%b2%d0%b0%d0%bd%d0%b8%d0%b5-garetosmab-%d0%bf%d1%80%d0%b8%d0%be%d1%81%d1%82%d0%b0%d0%bd%d0%be%d0%b2%d0%bb%d0%b5%d0%bd%d0%be-%d0%b2-%d0%b8%d1%81%d0%bf%d1%8b%d1%82\/","title":{"rendered":"\u0414\u043e\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 Garetosmab \u041f\u0440\u0438\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u043e \u0432 \u0418\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u0438 LUMINA-1 \u0434\u043b\u044f \u041b\u0435\u0447\u0435\u043d\u0438\u044f \u0424\u041e\u041f"},"content":{"rendered":"<p>\u0425\u043e\u0442\u044f \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u0447\u0440\u0435\u0437\u0432\u044b\u0447\u0430\u0439\u043d\u043e \u043f\u043e\u043b\u0435\u0437\u043d\u044b \u043f\u0440\u0438 \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u043a\u0435 \u043d\u043e\u0432\u044b\u0445 \u043c\u0435\u0442\u043e\u0434\u043e\u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u044f, \u043d\u0435 \u0432\u0441\u0435 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f \u043f\u0440\u043e\u0445\u043e\u0434\u044f\u0442 \u043f\u043e \u043f\u043b\u0430\u043d\u0443. \u041d\u0435\u0434\u0430\u0432\u043d\u043e \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u044f Regeneron Pharmaceuticals (\u00abRegeneron\u00bb) \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u043b\u0430 \u044d\u0442\u043e \u0432\u043e\u043e\u0447\u0438\u044e. \u041a\u0430\u043a \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u044f \u043e\u0431\u044a\u044f\u0432\u0438\u043b\u0430 \u0432 <a href=\"https:\/\/www.biospace.com\/article\/regeneron-hits-pause-on-lumina-1-trial-due-to-concerns-with-garetosmab\/\">\u043f\u0440\u0435\u0441\u0441-\u0440\u0435\u043b\u0438\u0437\u0435<\/a>, \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u0444\u0430\u0437\u044b 1 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f LUMINA-1 \u043f\u0440\u043e\u0438\u0437\u043e\u0448\u043b\u0438 \u0441\u0435\u0440\u044c\u0435\u0437\u043d\u044b\u0435 \u043f\u043e\u0431\u043e\u0447\u043d\u044b\u0435 \u0440\u0435\u0430\u043a\u0446\u0438\u0438. \u0418\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u0435 \u043f\u0440\u0435\u0434\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u043e \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 garetosmab (REGN2477) \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0435\u0439 \u043e\u0441\u0441\u0438\u0444\u0438\u0446\u0438\u0440\u0443\u044e\u0449\u0435\u0439 \u0444\u0438\u0431\u0440\u043e\u0434\u0438\u0441\u043f\u043b\u0430\u0437\u0438\u0435\u0439 (\u0424\u041e\u041f). \u041e\u0434\u043d\u0430\u043a\u043e \u0438\u0437-\u0437\u0430 \u0442\u044f\u0436\u0435\u043b\u044b\u0445, \u0430 \u0438\u043d\u043e\u0433\u0434\u0430 \u0438 \u0441\u043c\u0435\u0440\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0440\u0435\u0430\u043a\u0446\u0438\u0439, Regeneron \u043f\u0440\u0438\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u0438\u043b \u043f\u0440\u0438\u0435\u043c \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u0432 \u0445\u043e\u0434\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/p>\n<h2>\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 LUMINA-1<\/h2>\n<p>\u0412 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 LUMINA-1 \u043f\u0440\u0438\u043d\u044f\u043b\u0438 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 44 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 (\u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 18-60 \u043b\u0435\u0442). \u0412 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u0430\u0447\u0430\u043b\u044c\u043d\u043e\u0433\u043e 28-\u043d\u0435\u0434\u0435\u043b\u044c\u043d\u043e\u0433\u043e \u043f\u0435\u0440\u0438\u043e\u0434\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u044f, \u043a\u043e\u0433\u0434\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u044b \u043f\u043e\u043b\u0443\u0447\u0430\u043b\u0438 \u043b\u0438\u0431\u043e garetosmab, \u043b\u0438\u0431\u043e \u043f\u043b\u0430\u0446\u0435\u0431\u043e, \u044d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u043e\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0431\u044b\u043b\u043e \u043c\u043d\u043e\u0433\u043e\u043e\u0431\u0435\u0449\u0430\u044e\u0449\u0438\u043c. \u0424\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438, garetosmab \u0443\u043c\u0435\u043d\u044c\u0448\u0438\u043b \u043e\u043a\u043e\u0441\u0442\u0435\u043d\u0435\u0432\u0448\u0438\u0435 \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u044f \u043d\u0430 25% \u0438 \u043e\u0431\u043e\u0441\u0442\u0440\u0435\u043d\u0438\u044f \u0424\u041e\u041f \u043d\u0430 50%. \u041e\u0434\u043d\u0430\u043a\u043e \u0441\u0438\u0442\u0443\u0430\u0446\u0438\u044f \u0438\u0437\u043c\u0435\u043d\u0438\u043b\u0430\u0441\u044c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u043f\u0435\u0440\u0438\u043e\u0434\u0430 \u043f\u0440\u043e\u0434\u043b\u0435\u043d\u0438\u044f \u043e\u0442\u043a\u0440\u044b\u0442\u043e\u0433\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f, \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u043a\u043e\u0442\u043e\u0440\u043e\u0433\u043e \u0432\u0441\u0435 44 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 \u043f\u043e\u043b\u0443\u0447\u0438\u043b\u0438 garetosmab. \u0422\u0435\u043f\u0435\u0440\u044c \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u0435 \u043f\u0440\u0438\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u043e, \u043f\u043e\u043a\u0430 Regeneron \u0438 \u0434\u0440\u0443\u0433\u0438\u0435 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0438\u0435 \u043a\u043e\u043c\u0438\u0442\u0435\u0442\u044b \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u044e\u0442, \u043a\u0430\u043a\u0443\u044e \u0440\u043e\u043b\u044c garetosmab \u0441\u044b\u0433\u0440\u0430\u043b \u0432 \u0441\u043c\u0435\u0440\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445.<\/p>\n<p>\u041f\u043e\u043c\u0438\u043c\u043e Regeneron, \u0444\u0430\u0440\u043c\u0430\u0446\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u044f Ipsen \u0442\u0430\u043a\u0436\u0435 \u0437\u0430\u043d\u0438\u043c\u0430\u0435\u0442\u0441\u044f \u043f\u043e\u0438\u0441\u043a\u043e\u043c \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u043c\u0435\u0442\u043e\u0434\u043e\u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0424\u041e\u041f. \u0412 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 MOVE \u0444\u0430\u0437\u044b 3 \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u044f Ipsen \u043f\u0440\u043e\u0430\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043b\u0430 \u043f\u0430\u043b\u043e\u0432\u0430\u0440\u043e\u0442\u0435\u043d \u043a\u0430\u043a \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u044b\u0439 \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0432\u0430\u0440\u0438\u0430\u043d\u0442. \u041d\u0430\u0431\u0440\u0430\u043d\u043e 107 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432. \u0412\u043e \u0432\u0440\u0435\u043c\u044f \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u044b \u043f\u043e\u043b\u0443\u0447\u0430\u043b\u0438 \u043f\u0430\u043b\u043e\u0432\u0430\u0440\u043e\u0442\u0435\u043d 5 \u043c\u0433 \u0435\u0436\u0435\u0434\u043d\u0435\u0432\u043d\u043e, \u0432 \u0442\u043e \u0432\u0440\u0435\u043c\u044f \u043a\u0430\u043a \u0434\u0440\u0443\u0433\u0438\u0435 \u043f\u043e\u043b\u0443\u0447\u0430\u043b\u0438 20 \u043c\u0433 \u0435\u0436\u0435\u0434\u043d\u0435\u0432\u043d\u043e \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 4 \u043d\u0435\u0434\u0435\u043b\u044c, \u0430 \u0437\u0430\u0442\u0435\u043c 10 \u043c\u0433 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 8 \u043d\u0435\u0434\u0435\u043b\u044c. \u0421 \u043e\u0434\u043d\u043e\u0439 \u0441\u0442\u043e\u0440\u043e\u043d\u044b, \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u043a\u0430\u0437\u0430\u043b\u0441\u044f \u043e\u0442\u043d\u043e\u0441\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u043c, \u0441\u043d\u0438\u0436\u0430\u044f \u0433\u0435\u0442\u0435\u0440\u043e\u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u043e\u0441\u0441\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u044e (\u0413\u041e) \u043d\u0430 62%. \u0412 \u0442\u043e \u0436\u0435 \u0432\u0440\u0435\u043c\u044f \u0443 67,7% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u043b\u0438\u0441\u044c \u043f\u043e\u0431\u043e\u0447\u043d\u044b\u0435 \u0440\u0435\u0430\u043a\u0446\u0438\u0438 \u0441\u0440\u0435\u0434\u043d\u0435\u0439 \u0438 \u0442\u044f\u0436\u0435\u043b\u043e\u0439 \u0441\u0442\u0435\u043f\u0435\u043d\u0438.<\/p>\n<div class=\"mod NFQFxe oHglmf xzPb7d viOShc\" lang=\"ru-US\" data-md=\"32\">\n<div id=\"media_result_group\" class=\"kno-mrg-si kno-mrg kno-swp\" data-hveid=\"CAgQAg\">\n<div class=\"kno-fiu kno-liu\">\n<div data-count=\"1\" data-hveid=\"CAYQAA\">\n<div class=\"umyQi\" data-h=\"130\" data-nr=\"1\">\n<div class=\"eA0Zlc ivg-i img-kc-m PZPZlf\" data-attrid=\"image\" data-docid=\"79R6gE8mbui1mM\" data-lpage=\"https:\/\/cyberleninka.ru\/article\/n\/progressiruyuschaya-ossifitsiruyuschaya-fibrodisplaziya-u-detey-obzor-literatury-i-analiz-5-klinicheskih-sluchaev\" data-ved=\"2ahUKEwi1p_Ogoo_tAhUDjlkKHW8MBPAQzkwoAHoECAYQAg\">\n<h2 class=\"fWhgmd\">\u041f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0430\u044f \u041e\u0441\u0441\u0438\u0444\u0438\u0446\u0438\u0440\u0443\u044e\u0449\u0430\u044f \u0424\u0438\u0431\u0440\u043e\u0434\u0438\u0441\u043f\u043b\u0430\u0437\u0438\u044f (\u0424\u041e\u041f)<\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>\u041f\u0440\u0438\u0431\u043b\u0438\u0437\u0438\u0442\u0435\u043b\u044c\u043d\u043e 1,3 \u043c\u0438\u043b\u043b\u0438\u043e\u043d\u0430 \u0447\u0435\u043b\u043e\u0432\u0435\u043a \u0432\u043e \u0432\u0441\u0435\u043c \u043c\u0438\u0440\u0435 \u0441\u0442\u0440\u0430\u0434\u0430\u044e\u0442 \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0435\u0439 \u043e\u0441\u0441\u0438\u0444\u0438\u0446\u0438\u0440\u0443\u044e\u0449\u0435\u0439 \u0444\u0438\u0431\u0440\u043e\u0434\u0438\u0441\u043f\u043b\u0430\u0437\u0438\u0435\u0439 (\u0424\u041e\u041f). \u042d\u0442\u043e \u0440\u0435\u0434\u043a\u043e\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u0432\u044b\u0437\u0432\u0430\u043d\u043e \u043c\u0443\u0442\u0430\u0446\u0438\u044f\u043c\u0438 \u0433\u0435\u043d\u0430 <em>ACVR1.<\/em> \u041e\u043d\u043e \u043d\u0430\u0441\u043b\u0435\u0434\u0443\u0435\u0442\u0441\u044f \u043f\u043e \u0430\u0443\u0442\u043e\u0441\u043e\u043c\u043d\u043e-\u0434\u043e\u043c\u0438\u043d\u0430\u043d\u0442\u043d\u043e\u043c\u0443 \u0442\u0438\u043f\u0443, \u0442\u043e \u0435\u0441\u0442\u044c \u0442\u0440\u0435\u0431\u0443\u0435\u0442 \u0442\u043e\u043b\u044c\u043a\u043e \u043e\u0434\u043d\u043e\u0439 \u0433\u0435\u043d\u043d\u043e\u0439 \u043c\u0443\u0442\u0430\u0446\u0438\u0438. \u041e\u0431\u044b\u0447\u043d\u043e <em>ACVR1<\/em> \u0441\u043f\u043e\u0441\u043e\u0431\u0441\u0442\u0432\u0443\u0435\u0442 \u0440\u043e\u0441\u0442\u0443 \u0438 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044e \u043a\u043e\u0441\u0442\u0435\u0439. \u041e\u0434\u043d\u0430\u043a\u043e \u044d\u0442\u0430 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href=\"https:\/\/patientworthy.com\/fibrodysplasia-ossificans-progressiva\/\">\u0424\u041e\u041f \u0437\u0434\u0435\u0441\u044c<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0425\u043e\u0442\u044f \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u0447\u0440\u0435\u0437\u0432\u044b\u0447\u0430\u0439\u043d\u043e \u043f\u043e\u043b\u0435\u0437\u043d\u044b \u043f\u0440\u0438 \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u043a\u0435 \u043d\u043e\u0432\u044b\u0445 \u043c\u0435\u0442\u043e\u0434\u043e\u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u044f, \u043d\u0435 \u0432\u0441\u0435 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f \u043f\u0440\u043e\u0445\u043e\u0434\u044f\u0442 \u043f\u043e \u043f\u043b\u0430\u043d\u0443. \u041d\u0435\u0434\u0430\u0432\u043d\u043e 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