Achard Thiers Syndrome

What is Achard Thiers Syndrome?

Achard-Thiers Syndrome is characterized by type 2 (insulin-resistant) diabetes mellitus and signs of androgen excess. In women of reproductive age, Androgen excess is the most common endocrine disorder. Achard-Thiers Syndrome is also known as diabetic-bearded woman syndrome.

What are the symptoms of Achard Thiers Syndrome?

Common symptoms of Achard-Thiers Syndrome are related to Androgen excess and include the following:

• Excess hair male pattern hair growth in females
• Diabetes mellitus
• Voice changes
• Absent menstruation
• Sparse menstruation
• Excessive hair growth
• Facial acne
• Increased blood pressure
• Obesity

What causes Achard Thiers Syndrome?

The exact cause of Achard-Thiers Syndrome is not completely understood. Diabetes is a major contributor to the cause of this disease. Insulin deficiency is a haulmark of diabetes and the obesity symptom of Achard Thiers Syndrome can make it worse.

How is Achard Thiers Syndrome diagnosed?

Physical examination and laboratory testing are used to diagnose the syndrome. Women who have Achard-Thiers Syndrome will have high levels of insulin in their body, this is called hyperinsulinemia. Because of that, a two-hour oral glucose tolerance test will be used to show the abnormally elevated levels of glucose in the blood.

What are the treatments for Achard Thiers Syndrome?

Managing the symptoms is the primary goal. Insulin or other medications and diet can be used to control the diabetes. Hair removal and other cosmetic touch ups can also help. Younger woman are usually put on an oral contraceptive for hormone replacement. Hormone replacement therapy is the most common approach for women who are postmenopausal.

Where can I find out more about Achard Thiers Syndrome?

• NIH
• NORD
• Check Orphan