FDA Approves Novel Deep Brain Stimulator for Parkinson’s Disease

As reported in Michael J. Fox News, the FDA has just approved the novel Percept PC Neurostimulator, a device inserted into the brain of patients with Parkinson’s to administer deep brain stimulation therapy. The new technology delivers therapy through electric signals, while simultaneously picking up on and recording brain signals in order to give doctors more insight into what’s causing the patient’s symptoms and experience. This new scope will show physicians the relationship between symptoms and the precise brain signaling that accompanies it.

Parkinson’s Disease

Parkinson’s disease is a neurological disorder that affects patient’s movement and mobility. The progressive disorder begins with slight tremors and rigidity, and advances into greater loss of balance, difficulty with speech, rigid muscles, slowness, difficulty walking or standing, and occasionally hallucinations and delusions. It develops when neurons that normally are responsible for dopamine die off, which would normally be responsible for communication between the brain and muscles. The disease tends to develop later in life, usually developing after age 50.

What is Deep Brain Stimulation?

Deep brain stimulation is a technique used in a treatment regime for neurological disorders such as Parkinson’s, essential tremordystoniaepilepsy, and obsessive-compulsive disorder. The device acts like a pacemaker for the brain. Itimplanted in the brain to act as an artificial electrode, using tiny wires to send electrical signals to different brain regions to improve the brain functioning. By picking up some of the work, patients tend to experience less symptoms related to motor skills.
Though three deep brain stimulation is already approved by the FDA, this is the first that can simultaneously monitor the patient’s brain activity as they receive the therapy. This allows doctors to analyze the patient’s firsthand description of their experience and compare it to which parts of the brain are lit up. Dr. Joohi Jimenez-Shahed said to Dr. Rachel Dolhun of Michael J Fox News:
“This device allows us to measure and record brain signals, which can be matched with a person’s symptoms as reported in the diary or what we see on exam. By looking at brain signals, we might be able to tell whether symptoms relate to medication wearing off or to dyskinesia, for example, and we can use this information to more precisely understand how a patient’s symptoms respond to DBS.”
Deep brain stimulation is a relatively modern treatment, doctors already are discussing how to adapt the technology to be more personalized to the patient in a method known as adaptive therapy. They expect the devices will be able to pick up on what the patient needs, sensing if a medication isn’t working or a symptom is flaring up, and apply the electrical signals as needed. They expect this next step to be groundbreaking in Parkinson’s treatment, and could potential be in trials by the end of 2020.

What are your thoughts on this new form of deep brain stimulation? Share your stories, thoughts, and hopes with the Patient Worthy community!

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