Researchers Illuminate Link Between Type 2 Diabetes, Chronic Kidney Disease, and Left Ventricular Strain

A study has recently highlighted the fact that patients who have type 2 diabetes are more susceptible to chronic kidney disease (CKD), and as a result, cardiac issues. This study examines how this comorbidity can increase the risk of cardiovascular mortality.

The Study

The primary aim of this investigation was to confirm whether or not chronic kidney disease leads to deterioration of the left ventricular myocardial strain. Additionally, the researchers wanted to evaluate what risk factors may be associated with this  development.

If we can better understand what makes a condition more likely to occur, we can  begin to take steps for prevention.

The study included a total of 105 individuals who had type 2 diabetes and 52 individuals who were healthy. All participants had their baseline health examined prior to the study. They then all underwent a cardiac magnetic resonance examination.

Of those who had diabetes, patients were separated based on whether or not they currently had chronic kidney disease or not. In total, 33 patients had CKD, and 72 did not have the condition.

Researchers examined the function of the LV as well as global strain parameters. These measures were then compared across the control groups and the two groups of patients with diabetes.

Pearsons correlation coefficients were used to understand the correlation between clinical factors measured prior to the study and the LV strain parameters.

The team also used a regression analysis to understand the independent indicators for strain of the LV.

The Findings

The investigators on this study found that the diabetes patients who did not have chronic kidney disease were significantly less likely to have elevated LV strain indicators.

Type 2 diabetes patients who did have CKD had lower magnitudes of radial, longitudinal, and circumferential PS. They also had lower peak diastolic strain rates than the controls or those patient who didn’t have CKD.

Overall, this research team has demonstrated that chronic kidney disease can lead to a deteriorated LV strain in individuals who are already living with type 2 diabetes. The LV strain had a positive association with eGFR. It also had a negative association with uric acid. Researchers believe that uric acid may be an independent factor that can help predict reduction of the LV strain,

You can read more about this study and its findings here.

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