A recent study has investigated the association between cardiovascular disease risk factors and fat distribution. Researchers used linear regression analyses and adjusted for insulin sensitivity and other factors.

Previous research had found that there was an association between proteinuria, metabolic syndrome, and incident chronic kidney disease (CKD).

Study Results

The primary goal of this study was to investigate how the various components of metabolic syndrome may be associated with both end-stage renal disease (ESRD) and death. All patients in this study had stage 3 or stage 4 CKD. All participants were identified using a patient registry.

60% of the people in this study had metabolic syndrome. Some of the components of this syndrome are associated with a higher risk of ESRD. These include high triglycerides, hypertension, and impaired glucose metabolism. Additionally, impaired glucose metabolism and low HDL cholesterol were associated with an increased risk of death.

The study found that for men, larger LFM was related to lower HDL cholesterol and TGs. Additionally, they were associated with lower LDL cholesterol and fasting insulin levels. For women, the larger LFM was related with with all favorable CVD risk factors. However, these results were not statistically significant.

For both men and women, a larger TFM was associated with an unfavorable cardiovascular disease risk. Additionally, these did not change after adjusting for insulin sensitivity.

The researchers concluded that metabolic syndrome is positively associated with ESRD. However, it is not associated with death in those living with Stage 3 or Stage 4 CKD.

You can read more about this study, its findings, and what it could mean for patients here.