Acro Dermato Ungual Lacrimal Tooth Syndrome

What is Acro Dermato Ungual Lacrimal Tooth Syndrome?

Acro Dermato Ungual Lacrimal Tooth Syndrome (ADULT) is an inherited disease that affects the teeth, nails, hair, extremities and the sweat glands. It is a form of of ectodermal dysplasia

What are the symptoms of Acro Dermato Ungual Lacrimal Tooth Syndrome?

Common symptoms of ADULT include the following:

• Excessive freckling
• Split hand, cleft hand
• Distortion of the index finger
• Tear duct obstruction/ lacrimal duct anomalies
• Early loss of permanent teeth
• Chronic skin infection
• Dry skin
• Thick toenails
• Fine hair

What causes Acro Dermato Ungual Lacrimal Tooth Syndrome ?

The syndrome arises from a mutation in the TP63 gene. ADULT is passed along through autosomal dominant inheritance. Patients with ADULT inherit the abnormal gene from only one parent. Many times, one of the patient’s parents also has ADULT. An affected individual has a 50% chance of passing the gene to a son or daughter. How is Acro Dermato Ungual Lacrimal Tooth Syndrome diagnosed? Acro Dermato Ungual Lacrimal Tooth Syndrome can be diagnose via the patient’s physical features. The definitive diagnosis usually relies upon genetic testing.

What are the treatments for Acro Dermato Ungual Lacrimal Tooth Syndrome?

The use of beta blocker medications are effective in 90 per cent of cases. In other cases, surgery might be appropriate.

Where can I find out more about Acro Dermato Ungual Lacrimal Tooth Syndrome?

• NIH
• NFED
• Check Orphan