Liposarcoma

What is liposarcoma?

Liposarcoma is a cancer that originates in fat cells. It is a form of soft tissue sarcoma that typically affects older adults. This cancer tends to begin in the abdomen or limbs, but has the potential to grow anywhere. 

What are the symptoms of liposarcoma?

Depending on the location of the tumor, the symptoms of this cancer can differ. Here are the symptoms for the two most common locations of liposarcoma. 

Tumors in the arms and legs result in a growing lump under the skin, swelling, pain, and weakness in the affected limb.

If the cancer begins in the abdomen, symptoms include pain and swelling in the abdomen, a feeling of fullness, blood in the stool, and constipation. 

What causes liposarcoma?

The cause of this cancer is unknown. Medical professionals are aware that mutations in the DNA of fat cells result in rapid multiplication and prolonged life of cells but unsure of why these mutations occur. 

How is liposarcoma diagnosed?

Multiple tests will be used to diagnose this cancer. Doctors may order X-rays, MRIs, CT scans, or biopsies. After confirming that one has liposarcoma, they will conduct further tests to discover which type of cells are involved. This information helps to know prognosis and treatment options. These tests include immunohistochemistry, cytogenetic analysis, molecular genetic testing, and fluorescence in situ hybridization. 

What are the treatments for liposarcoma?

There are multiple treatment options for liposarcoma, including surgery, radiation, chemotherapy, and clinical trials. 

Where can I find out more about liposarcoma?

• • Mayo Clinic
  • The Liddy Shriver Sarcoma Initiative
  • NORD