You may not know this but Shakespeare’s signature is super rare, there are only six known authentic signatures of his in the world.

You know what else is rare? People with Afibrinogenemia. About 5 out of 10 million people have this disorder, and even rarer than that is Hypofibrogenemia. These plus Dysfibrogenemia (which effects 1 in 1 million people) are different types of Factor I Deficiency, or fibrinogen deficiency.

People with this deficiency are missing fibrinogen, a protein in the blood plasma that is needed in the body’s process of forming blood clots. The different types of Factor I Deficiency describe how low the fibrinogen level is, or if it is malfunctioning.

Here are some links for more info:
Hemophilia.ca
WFH.org