Stand Up To Cancer Gives $10 million Towards Multiple Myeloma Research

The charity organisation Stand Up To Cancer (SU2C) has just announced that $10 million is going to be given to a team of researchers to fund their work to improve multiple myeloma diagnoses, reports kait8.

Multiple myeloma is a form of cancer that affects the bone marrow. It often occurs in many different areas of the body at once, such as the skull, spine, ribs, and pelvis. The disease is most common in men, those over sixty, people of African descent, and those with a family history of the illness. Myeloma can be a particularly dangerous form of cancer because its lack of early symptoms means that it’s often not caught until has already reached a late stage. After the disease has significantly progressed, people affected may experience tenderness in their bones, kidney problems, recurrent infections, bone fractures, and anaemia that manifests as tiredness, shortness of breath, and weakness. Very few people recover from the illness, and treatment focuses on slowing its progression and managing symptoms.

Early diagnosis is therefore crucial for improving the prognosis for patients with myeloma, but this can be difficult due to the lack of early symptoms. The new SU2C ‘Dream Team’ will use the $10 million award to tackle this problem. They have announced their plans to research precursor conditions that are significant risk factors for the development of myeloma. That way, patients who display the high-risk markers can be carefully monitored so that doctors catch myeloma as soon as it first appears and intervene. Furthermore, the team will work on treatments that can be taken by people with the high-risk precursor or early disease stages.

To do this, the scientists are planning on carrying out a large-scale study of myeloma in the United States. The will begin by analysing blood samples from 50,000 at-risk people, most of whom will have relatives with the disease or be African American. The researchers will look for evidence of two precursor conditions: monoclonal gammopathy of undetermined significance, and smoldering multiple myeloma (SMM). Statistically, they expect to find a subset of approximately 3,000 people from the sample with one of these two conditions. The team will then follow up this subset to investigate what biomarkers can be used to establish a high risk of developing myeloma in a person. They will also work on developing treatments for myeloma and SMM that patients can use before the disease progresses.
The team will be led by two associate professors: Irene Ghobrial, MD, and Ivan Borrello, MD. Through early detection and observation of multiple myeloma the researchers hope to gain a better understanding of the course of the disease, which they can use to create treatments and interventions that they hope will halt its progression at an early stage.

Anna Hewitt

Anna Hewitt

Anna is from England and recently finished her undergraduate degree. She has an interest in medicine and enjoys writing. In her spare time she likes to cook, hike, and hang out with cats.

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