How a Fluocinolone Acetonide Implant May Improve Uveitis Treatment

Could an ocular implant be an effective therapeutic solution for individuals living with noninfectious uveitis? According to an article in HCP Live, the answer seems to be yes. A study performed by researchers from the University of Colorado Sue Anschutz-Rodgers Eye Center, and led by Dr. Amit K. Reddy, found that utilizing a 0.18mg fluocinolone acetonide implant could effectively manage choroiditis (also known as posterior uveitis). 

Within the study, published in Ophthalmology Retina, the research team performed a retrospective analysis using data from individuals who received this implant over a specific two-year period. Data included information on visual acuity, corticosteroid treatments, intraocular pressure, and more. Included participants had at least six months of follow-up following implantation. Altogether, data from 42 patients was included in the study; 64 total eyes were evaluated. Findings show that:

  • The use of corticosteroids prior to implant administration did not improve the implant’s efficacy. In fact, patients who received short-acting corticosteroids prior to the implant were more likely to experience a uveitic recurrence. 
  • Younger individuals were less likely to experience recurrent uveitis and inflammation following the implant than older individuals. 
  • Altogether, the implant increased the probability of remaining in remission by 68.8% within six months and 52.6% within one year. 
  • 15.6% of participants required additional eyedrops and 4.7% required surgery even following implantation. 

More research is needed to better understand the potential efficacy of this treatment and who might be the best patients to utilize it. 

About Uveitis

Uveitis refers to inflammation in the uvea, or the middle layer of the eye that provides blood supply to the retina. It can affect one or both eyes, and the specific subtype depends on the inflamed area. Posterior uveitis, or choroiditis, is the most uncommon form and affects the retina and/or optic nerve. Cyclitis, or intermediate uveitis, affects the ciliary body. Finally, iritis, or anterior uveitis, is the most common form and affects the front of the eye. 

Uveitis is often connected with other conditions such as autoimmune or inflammatory disorders. Eye injury or surgery, infection, or cancers may also cause uveitis. Symptoms may include:

  • Eye pain and redness
  • Blurred vision
  • “Floaters” in one’s vision
  • Reduced visual acuity
  • Increased light sensitivity 
  • Difficulty seeing colors or seeing in the dark
  • Retinal detachment
  • Vision loss 

Treatment options include eye drops, steroids, surgery, anti-inflammatory medications, antivirals, and antibacterials. If you are experiencing symptoms, please speak with your doctor as soon as possible. 

Jessica Lynn

Jessica Lynn

Jessica Lynn has an educational background in writing and marketing. She firmly believes in the power of writing in amplifying voices, and looks forward to doing so for the rare disease community.

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