Madrigal Reports Encouraging 2-Year Data for Treating Cirrhosis

ACKNOWLEDGEMENT – Patient Worthy is honored to partner with The Fatty Liver Foundation to provide you with this article. The Fatty Liver Foundation aims to improve the diagnosis, treatment & support of Americans with fatty liver, NAFLD or NASH through awareness, education, screening and patient advocacy.

Madrigal has reported encouraging results from their ongoing Maestro NASH extension trial.

The Maestro-NASH Open Label Extension is crucial for understanding how resmetirom performs in F4 compensated NASH patients. By evaluating long-term safety, fibrosis regression, and disease progression prevention, the study offers hope for addressing the needs of this high-risk population and advancing treatment options for advanced NASH. Currently the drug is only approved for F2/F3 patients. The more serious F4 disease still has no approved therapy and many in our community suffer from it.

With F4 disease one of the deadliest complications is portal hypertension.

There is a long way to go before we might see approval for F4, but here are some 2 year results. You can see that just over half of the patients saw an improvement of at least 25% in their stiffness and 35% moved from F4 to F3. This greatly reduces the risk of complications from portal hypertension. This is extremely important as many of us have been told that F4 is unlikely to improve. I’m personally a patient that has been able to improve my situation but I know many who have not. Getting a useful drug approved for treatment of more advanced disease is tremendously important for us.

There is lots of info on our website if you want to pursue it.

The foundation has expanded our broader outreach to support efforts to find a better way. We have two impact projects, The Wellness League, and Sober Livers which reach beyond the concerns of drug development and focus on the needs of people who seek to live healthier lives and avoid liver disease.

The Wellness League Local Search Tool

Many people don’t know what services are available to them in their local area. Finding those local resources in their local zip code is often a challenge. We are developing a tool to help with that. Just click on the link: enter your local zip-code in the form: to explore the services available to you in your area.

https://soberlivers.org/

In June 2024 Sober Livers, a new groundbreaking organization for patients with alcohol use disorder and alcohol-related liver disease, launched with great success. Patients seeking support that only comes from those that have walked in the same shoes suddenly realize they are not alone.

We can’t press the system to do better if we can’t show them data that change is needed, so please join us by clicking the link and take the survey.