I just read an interesting article that explains how individuals with active Acromegaly have less fat and more muscle than those without Acromegaly.
They also have more GH and perhaps IGF-l (a growth factor not unlike insulin). GH and IGF-l actually have several detrimental effects on the body’s insulin processing, making it more insulin resistant.
Do despite being leaner, people with acromegaly are more likely to develop diabetes.
In addition, these excessive secretions lead to atypical fat distribution, with more fat in the trunk and internally, and less even distribution of adipose tissue.