Chronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency disorder that impairs the body’s ability to kill certain bacteria and fungi.
As a result, people with CGD are at a higher risk for getting severe, unusual, and repeat infections. Approximately 20 children are born with CGD in the United States every year, 85% of whom are boys. CGD may become apparent at any time from infancy to late adulthood; however, most affected individuals are diagnosed before age 5 years.
Here are some of the signs and symptoms that may indicate it’s appropriate to test for CGD:
- Serious, unusual, and repeat infections in many areas of the body, including the lungs, liver, and bones
- Skin and soft tissue abscesses that don’t go away
- Diarrhea or abdominal pain
- Pain or difficulty eating or going to the bathroom
- Vomiting after meals
- Swollen lymph nodes
- Fever, cough, fatigue, or bone/joint pain
- Failure to thrive
- Granulomas, which usually appear in the bladder and intestines
- Family members or relatives who have had unusual or serious infections that have resulted in hospitalizations or even death
Patients looking for more information about CGD can visit CGD Connections, a multi-faceted online platform and Facebook page that was created as a resource for the community in partnership with people living with CGD and their communities.
More information is also in a document about Understanding the roots of CGD, here.
With thanks to the Jeffrey Modell Foundation.