In a late July 2022 news release, immunodermatology innovator KSL Beutner Laboratories shared that it had launched an indirect immunofluorescence (IIF) serum blood test within the United States. The IIF serum blood test can identify laminin 332. This antigen has been linked to mucous membrane pemphigoid (MMP).
In the past, it has been difficult to concretely identify and diagnose patients with mucous membrane pemphigoid due to misdiagnosis and other issues. For example, BP180 and laminin 332 are autoantigens which are most commonly found in those with mucous membrane pemphigoid. In fact, approximately 33% of individuals have the form related to laminin 332. But did you know that no serum blood tests were available, in the United States, that would test for this specific form? As a result, individuals were left experiencing lower quality of life (QOL) as well as worsening pain prior to receiving an accurate diagnosis.
The IIF serum blood test developed by KSL Beutner Laboratories has the potential to greatly change the diagnostic and treatment field. The serological assay is able to provide a confirmed diagnosis within 72 hours of testing, allowing patients to pursue quicker treatment. It is the first test of its kind approved within the country and has 84% sensitivity and 99% specificity.
KSL Beutner Laboratories is now approved to perform this testing within its laboratory space in Buffalo, New York. To learn more about testing or other related information, take a look at the company website.
What is Mucous Membrane Pemphigoid (MMP)?
Both pemphigus and pemphigoid are rare autoimmune blistering diseases of the skin. Mucous membrane pemphigoid (MMP) refers to a group of chronic blistering disorders affecting the skin’s mucous membranes, most often of the eyes and mouth. MMP affects females 2x more than males, and most commonly occurs between ages 60-80. However, individuals of other ages may also be affected. Though MMP is considered an autoimmune disease, the exact cause is unknown. Some researchers think certain individuals may have a genetic predisposition to mucous membrane pemphigoid.
Symptoms and complications related to mucous membrane pemphigoid can (but do not always) include:
- Recurrent blistering skin lesions (and scarring in the affected areas)
- Red, tender gums that bleed easily and tend to slough off
- Glaucoma
- Conjunctivitis
- Difficulty swallowing
- Voice hoarseness
- Esophageal narrowing
- Alopecia
- Urinary or sexual dysfunction
- Scared ocular mucosa and vision loss or blindness
- Increased risk of adenocarcinoma in the genital mucosa, lungs, and gastrointestinal mucosa
