AIV001 (axitinib): a potential, non-surgical therapeutic option for people with basal cell carcinoma (BCC). AiViva Biopharma describes AIV001 as:
a novel formulation of a multi-kinase inhibitor combined with AiViva’s proprietary delivery technology, designed for prolonged drug release via intradermal treatment. AIV001 targets multiple pathways to reduce fibroplasia in overlapping phases of wound healing and scarring; targets VEGFR to limit the inflammation and fibrosis associated with rosacea; and inhibits or reduces neovascularization and cell proliferation.
According to reporting by Healio, researchers recently evaluated AIV001 within a Phase 1/2 clinical trial. 26 individuals with mixed, modular, or superficial basal cell carcinoma enrolled.
During the course of the study, the 26 participants were entered into four different treatment groups each focusing on a different dose. Researchers evaluated how tolerable the treatment was on skin, how safe it was, and how effective it was in clearing malignant (cancerous) cells. Researchers found that, at this point, AIV001 is well-tolerated. Moving forward, AiViva Biopharma plans to continue engaging in clinical development to advance the treatment.
What is Basal Cell Carcinoma (BCC)?
Basal cell carcinoma is a form of skin cancer that begins in basal cells on the surface/top layer of your skin. Because of this, basal cell carcinoma is most commonly found in areas of the skin with high sun exposure such as the head, neck, and face. An estimated 3.6 million people are diagnosed with BCC each year. Risk factors include having fair skin, being older in age, being immunocompromised, or having a family history of skin cancer. BCC may appear as:
- A scaly, flat patch of skin with a raised edge. This skin patch may appear to grow larger in size.
- Shiny, skin-colored bumps. In this manifestation, the bump may bleed or scab over.
- Brown, black, or blue lesions. In this case, the lesions often appear with a slightly raised or translucent border.
If you have BCC and are searching for support, consider checking out the support groups and resources from the Skin Cancer Foundation.
