Eosinophilic-associated disorders are a group of conditions characterized by heightened levels of eosinophils, which are a type of white blood cell within the immune system. One of these disorders is eosinophilic gastroenteritis (EGE). This rare disorder causes symptoms like abdominal pain and nausea due to high eosinophil levels in the stomach and small intestine. Interested in learning more? Well, keep reading for a better understanding of EGE.

About EGE

As we already stated, heightened levels of eosinophils cause EGE and related disorders. In a healthy body, eosinophils account for 5% of the white blood cells within the bloodstream. They are reserved for fighting off infections, especially those of parasitic origins. In those with EGE, there are increased levels of eosinophils in the stomach and small intestine specifically.

These heightened levels cause symptoms such as fatigue, vomiting, nausea, difficulty eating, weight loss, anemia, abdominal pain, and poor growth. These symptoms may vary from patient to patient. For example, some see fluid accumulation in the abdomen that results in bloating.

When it comes to causes, nobody knows what exactly is to blame. However, medical professionals have identified allergies as having a role in some way. In fact, risk factors for EGE include eczema, hay fever, and asthma. Additionally, this rare condition is more common in males, those between the ages of 20 and 50, and people with preexisting allergies.

Diagnosing EGE

Like many other rare diseases, diagnosing EGE can be difficult and take a long time. The similarity of its symptoms to other conditions – like Crohn’s disease – often leads to misdiagnosis. To properly diagnose EGE, doctors should follow these steps:

1. Perform a full medical examination
   1. This should include an evaluation of their medical history
2. Upon suspicion, order certain tests
   1. These tests include endoscopies, surgical biopsies, and allergy testing

Treating EGE

If a diagnosis is confirmed, treatment is the next step. While there is no cure, there are treatment options. These are dietary changes, nutritional support, anti-inflammatory drugs, and systemic steroids. Because EGE is a chronic condition, treatment is ongoing and will require continued support from a team of specialists. This team should include a dietician, allergist, and gastroenterologist.

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