CAPS: When Genes Are Altered

Let’s take a trip back in time to the year 2001:

  • A new president is sworn into office;
  • the Global War on Terror begins;
  • and a discovery is made on the effects of an alteration to a gene.
A “gene” is altered…the result? CAPS!
(Source: Shutterstock)

According to the Mediators of Inflammation journal, this gene, called NLRP3, is altered in at least 60% of patients who have what is known as cryopyrin associated periodic syndrome (CAPS), a family of inherited inflammatory diseases such as Muckle-Wells Disease, Familial Cold Autoinflammatory Syndrome (FCAS) , and Neonatal-Onset Multisystem Inflammatory Disease (NOMID).

These CAPS patients aren’t the only ones affected by mutations in NLRP3.

Who else is affected?

Click here to read more about how the NLRP3 gene mutation plays a role in Inflammatory Bowel Disease, cardiovascular disease, rheumatoid arthritis, ankylosing spondylitis, celiac disease and more.

James Stone

James Stone

James grew up in Switzerland, in a little town on a little lake among the foothills of the Alps. His very English first name is owed to his Australian mother. During university, James worked as a freelance journalist covering local news in the little country's capital. Once he completed his studies in political science and media, James moved to Sydney where he joined a media monitoring company. He remained in the media monitoring industry even after his return to Switzerland. Eventually, love brought James to America, where he joined the Patient Worthy editorial team.

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