Breaking a system into small independent and interchangeable modules that can perform certain functions is called modularity.
For many years the KRAS oncogene proved to be a classic example of a target that did not respond to drugs. However, recent approval of drugs such as AMG510 and reported by Science Direct, enabled the successful targeting of certain mutations.
The goal of working with these modules is to convert a complex system into smaller, interchangeable modules making it easier to build, manage, upgrade and repair.
The Rise of Molecular Glue
In 2021 Science Direct published research highlighting the growing field of molecular glues. The glues are small molecules that cause protein interactions bringing about the destruction of previously undruggable proteins.
New advances in molecular glues since 2021 involve the integration of additional target proteins and expanding therapeutic applications.
As of 2021, new advances in molecular glues primarily involve artificial intelligence and drug design, plus the discovery of new target proteins and expanding therapeutic applications.
Pharma has shown increased interest in the development of clinical candidates for autoimmune diseases.
From 2021-2025, molecular glue research had a significant increase. It shifted from discovery to using Artificial Intelligence to design computational modeling and targeting proteins that heretofore had been “undruggable”.
