A Breakthrough in Avacopan Measurement: New LC-MS/MS Method Enables Precision Monitoring in Vasculitis Patient

Avacopan, a novel oral therapy for antineutrophil cytoplasmic antibody-associated vasculitis (ANCA-AAV), has changed treatment paradigms for this rare but serious disease. However, until now, a validated technique for measuring avacopan…

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Updated ANCA-Associated Vasculitis Guidelines Aim to Improve Care
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Updated ANCA-Associated Vasculitis Guidelines Aim to Improve Care

According to a story from Medscape, a new set of guidelines from the Kidney Disease: Improving Global Outcomes (KDIGO) aims to improve and update standards of care for antineutrophilic cytoplasmic…

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Granulomatosis with Polyangiitis: Removal of Wisdom Teeth Eventually Led to a Lung Transplant for this Teen
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Granulomatosis with Polyangiitis: Removal of Wisdom Teeth Eventually Led to a Lung Transplant for this Teen

Lonnie's mother, Stephanie Pesterfield of Colorado Springs, still finds it difficult to talk about her son Lonnie’s near-death experience. Yet as published recently in People, Stephanie and her son want…

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Could AI Predict Vasculitis and Spondyloarthritis?
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Could AI Predict Vasculitis and Spondyloarthritis?

It’s no secret that receiving a rare disease diagnosis can take excess amounts of time. Various articles share that, on average, it takes anywhere from four to nine years for…

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Seventeen Pediatric Patients Had Spontaneous Recovery From IgA Vasculitis-Associated Nephritis
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Seventeen Pediatric Patients Had Spontaneous Recovery From IgA Vasculitis-Associated Nephritis

  A recent article published in Physicians Weekly and also by the National Institute of Health stated that immunosuppressive medication and kidney biopsies may not be necessary if children with…

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ICYMI: Patients with a Certain Genotype Are More Likely to Discontinue Imuran Due to Toxicity

  Dr. Cecilia Chung and associates at the Vanderbilt University’s Medical Center conducted a study published recently in MedPage Today. Results showed that patients who had inflammatory disorders, as well…

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Two Teenage Boys Diagnosed With ANCA-Associated Vasculitis, Part One

A group of autoimmune diseases called anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is the subject of a preprint under consideration at Pediatric Rheumatology. ANCA-AAV is characterized by damage to small…

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 Two Recent FDA and EMA Approvals Bring Hope to ANCA Associated-Vasculitis Patients
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 Two Recent FDA and EMA Approvals Bring Hope to ANCA Associated-Vasculitis Patients

   ANCA-associated vasculitis (AAV) generally targets two enzymes, myeloperoxidase (MPO) or proteinase 3 (PR3) located in the granules of monocytes and neutrophils. These enzymes play a critical role in the…

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New Therapy for Eosinophilic Granulomatosis with Polyangiitis May be Coming to Europe

The EMA has recently published their recommendation for extending the indication of a treatment called Nucala to include patients diagnosed with relapsing-remitting or refractory eosinophilic granulomatosis with polyangiitis (EGPA). Specifically,…

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TAVNEOS Approved in Japan for ANCA-Associated Vasculitis
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TAVNEOS Approved in Japan for ANCA-Associated Vasculitis

Sometimes, certain drugs may be approved in different countries and not in others. However, drug approval spanning multiple countries highlights the importance of getting drugs and treatments into the hands…

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Approval Application for ANCA-Associated Vasculitis Drug Amended by Developer
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Approval Application for ANCA-Associated Vasculitis Drug Amended by Developer

According to a story from ANCA Vasculitis News, the biopharmaceutical company ChemoCentryx has recently made an amendment to its approval application for its investigational therapy. This therapy, called avacopan, is…

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Managing Antineutrophil Cytoplasmic Antibody (ANCA) Vasculitis
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Managing Antineutrophil Cytoplasmic Antibody (ANCA) Vasculitis

According to an article in Healio, Dr. Anisha Dua recently addressed attendees at the ACR Clinical Symposium on the subject of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Dr. Dua is the…

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A Combination of Nucala and Corticosteroids Was Shown to Increase Remission in EGPA
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A Combination of Nucala and Corticosteroids Was Shown to Increase Remission in EGPA

Corticosteroids are used to treat a wide variety of inflammatory conditions, with asthma and arthritis acting as examples. However, these drugs can result in a variety of side effects, such…

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Study of the Week: Nucala’s Effectiveness in EGPA Confirmed in Real-World Study
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Study of the Week: Nucala’s Effectiveness in EGPA Confirmed in Real-World Study

Welcome to Study of the Week from Patient Worthy. In this segment, we select a study we posted about from the previous week that we think is of particular interest…

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Nucala and Corticosteroids Can Increase EGPA Remission

Recently, researchers sought to examine how Nucala (mepolizumab) affected disease progression in patients with eosinophilic granulomatosis with polyangiitis (EGPA), especially when used in conjunction with corticosteroids. According to ANCA Vasculitis…

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