Artiva Halts AlloNK Autoimmune Program Following Two Trial Deaths and Major Workforce Reduction

As reported on Medical Daily, Artiva Biotherapeutics has discontinued development of its investigational autoimmune cell therapy, AlloNK, after two participant deaths occurred during a mid-stage clinical study. The San Diego-based…

Continue Reading Artiva Halts AlloNK Autoimmune Program Following Two Trial Deaths and Major Workforce Reduction

Johns Hopkins Researchers Identify Key Mechanism Linking Gut Bacteria to Colorectal Cancer

As reported by Science Daily, Researchers at Johns Hopkins have uncovered a long-sought explanation for how a toxin-producing gut bacterium contributes to colorectal cancer, identifying a cellular receptor that allows…

Continue Reading Johns Hopkins Researchers Identify Key Mechanism Linking Gut Bacteria to Colorectal Cancer

Rituximab May Help Stabilize or Reduce Calcinosis in Dermatomyositis, Small Case Series Suggests

Calcinosis remains one of the most difficult complications to manage in patients with dermatomyositis (DM) and juvenile dermatomyositis (JDM), often causing pain, disability, and reduced quality of life. New findings…

Continue Reading Rituximab May Help Stabilize or Reduce Calcinosis in Dermatomyositis, Small Case Series Suggests

FDA Begins Review of uniQure Gene Therapy Candidate for Huntington’s Disease

As reported by the Manila Times, the FDA has formally accepted uniQure’s biologics license application for ifezuntirgene inilparvovec (AMT-130), an experimental gene therapy being developed for people living with Huntington’s…

Continue Reading FDA Begins Review of uniQure Gene Therapy Candidate for Huntington’s Disease

Open-Source Image Analysis Tool Provides Quantitative Assessment of MASH in Mouse Models

As published in Sage Journals, researchers have developed an accessible, machine learning-driven histopathology workflow that enables quantitative evaluation of metabolic dysfunction-associated steatohepatitis (MASH) in laboratory mice without requiring coding expertise…

Continue Reading Open-Source Image Analysis Tool Provides Quantitative Assessment of MASH in Mouse Models

Spatial Mapping Study Uncovers Distinct Molecular Changes Across Liver Regions in MASH

As reported on Bioengineer and ScienMag, a new spatial transcriptomics study has provided fresh insight into how different regions of the liver are remodeled during metabolic dysfunction-associated steatohepatitis (MASH). By…

Continue Reading Spatial Mapping Study Uncovers Distinct Molecular Changes Across Liver Regions in MASH

Alentis Deepens ADC Strategy Through New Claudin-1 Collaboration With PinotBio

As reported on Pharmaceutical Technology, Alentis Therapeutics has expanded its efforts in claudin-1-targeted cancer therapeutics through a newly announced partnership with PinotBio, aimed at generating antibody-drug conjugates (ADCs) for multiple…

Continue Reading Alentis Deepens ADC Strategy Through New Claudin-1 Collaboration With PinotBio

Otsuka’s Phase 3 VISIONARY Study Suggests Voyxact May Alter Disease Course in IgA Nephropathy

Final two-year data from the Phase 3 VISIONARY trial indicate that Voyxact (sibeprenlimab-szsi) may significantly slow progression of primary immunoglobulin A nephropathy (IgAN), preserving kidney function and reducing the likelihood…

Continue Reading Otsuka’s Phase 3 VISIONARY Study Suggests Voyxact May Alter Disease Course in IgA Nephropathy

FDA Approves Belzutifan Plus Lenvatinib for Previously Treated Advanced Clear Cell Renal Cell Carcinoma

As reported on PharmaBiz, the US Food and Drug Administration (FDA) has approved the oral combination of belzutifan (Welireg) and lenvatinib (Lenvima) for adults with advanced renal cell carcinoma (RCC)…

Continue Reading FDA Approves Belzutifan Plus Lenvatinib for Previously Treated Advanced Clear Cell Renal Cell Carcinoma

AstraZeneca Expands AI-Driven Drug Discovery Efforts in MASH and Cardiomyopathy

As reported on BioSpace, AstraZeneca has entered a major artificial intelligence-focused research collaboration with biotechnology company insitro, committing up to $1.5 billion in potential payments to identify new drug targets…

Continue Reading AstraZeneca Expands AI-Driven Drug Discovery Efforts in MASH and Cardiomyopathy

Bristol Myers Squibb Wins FDA Expansion for Camzyos in Pediatric Obstructive Hypertrophic Cardiomyopathy

As reported on Yahoo! News, Bristol Myers Squibb (BMS) has received an expanded approval from the US Food and Drug Administration (FDA) for Camzyos (mavacamten), extending its use to pediatric…

Continue Reading Bristol Myers Squibb Wins FDA Expansion for Camzyos in Pediatric Obstructive Hypertrophic Cardiomyopathy

Wegovy Linked to Normal Liver Fat Levels in Small Analysis of Adults With Obesity

As reported on Medical Daily, small exploratory analysis suggests that semaglutide, the active ingredient in Wegovy, may substantially reduce liver fat in some adults with obesity. However, the findings come…

Continue Reading Wegovy Linked to Normal Liver Fat Levels in Small Analysis of Adults With Obesity

Phase 3 IMAgINATION Trial of Sefaxersen Meets Primary Endpoint in IgA Nephropathy

Investigational once-monthly therapy significantly reduced proteinuria versus placebo at 37 weeks, according to interim findings from the phase 3 study. As reported on PharmaBiz, Roche has reported positive interim findings…

Continue Reading Phase 3 IMAgINATION Trial of Sefaxersen Meets Primary Endpoint in IgA Nephropathy

FDA Grants Priority Review to Imfinzi-Enfortumab Vedotin Regimen for Muscle-Invasive Bladder Cancer

As reported on PharmaBiz, the FDA has accepted AstraZeneca’s supplemental Biologics License Application for durvalumab plus neoadjuvant enfortumab vedotin in patients with muscle-invasive bladder cancer who cannot receive or have…

Continue Reading FDA Grants Priority Review to Imfinzi-Enfortumab Vedotin Regimen for Muscle-Invasive Bladder Cancer

Singapore Approves Wegovy for MASH With Moderate to Advanced Liver Fibrosis

Semaglutide 2.4 mg becomes Singapore’s first approved therapy for adults with noncirrhotic metabolic dysfunction-associated steatohepatitis and F2-F3 fibrosis. As reported on the Manila Times, Singapore’s Health Sciences Authority (HSA) has…

Continue Reading Singapore Approves Wegovy for MASH With Moderate to Advanced Liver Fibrosis